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1

Design and synthesis of heterocyclic malonyl-CoA decarboxylase inhibitors

Jie-Fei Cheng, Mi Chen, Bin Liu, Zheng Hou, Thomas Arrhenius, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 174 KB

english, 2006

2

Conformationally constrained amino acids. Synthesis and optical resolution of 3-substituted proline derivatives

Chung, John Y. L., Wasicak, James T., Arnold, William A., May, Catherine S., Nadzan, Alex M., Holladay, Mark W.

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 879 KB

english, 1990

3

trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-proline

Holladay, Mark W., Lin, Chun Wel, May, Catherine S., Garvey, David S., Witte, David G., Miller, Thomas R., Wolfram, Caroline A. W., Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 412 KB

english, 1991

4

A Convenient Solution and Solid-Phase Synthesis of Δ5-2-Oxopiperazines via N-Acyliminium Ions Cyclization.

Jie-Fei Cheng, Mi Chen, Thomas Arrhenius, Alex Nadzan

Journal:

Year:

2002

File:

PDF, 30 KB

2002

5

Retinoic Acid Receptor Ligands Based on the 6-Cyclopropyl-2,4-hexadienoic Acid.

Luc J. Farmer, Lin Zhi, Susan Jeong, William W. Lamph, Deborah L. Osburn, Glenn Croston, Karen S. Flatten, Rich A. Heyman, Alex M. Nadzan

Journal:

Year:

2003

File:

PDF, 161 KB

2003

6

Novel Chromene Derivatives as TNF-α Inhibitors.

Jie-Fei Cheng, Akira Ishikawa, Yoshinori Ono, Thomas Arrhenius, Alex Nadzan

Journal:

Year:

2004

File:

PDF, 91 KB

2004

7

Design and synthesis of potential megacaloric parenteral nutrients

Stephen Hanessian, Christian Hoornaert, André G. Pernet, Alex M. Nadzan

Journal:

Carbohydrate Research

Year:

1985

Language:

english

File:

PDF, 188 KB

english, 1985

8

Synthesis of geometrically defined exocyclic olefins

Youssef L. Bennani, C.-K. Hwang, Stacie S. Canan Koch, Kristin S. Marron, Laura J. Dar-ti, Beth-Ann Badea, Alex M. Nadzan

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 221 KB

english, 1996

9

Novel chromene derivatives as TNF-α inhibitors

Jie-Fei Cheng, Akira Ishikawa, Yoshinori Ono, Thomas Arrhenius, Alex Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 153 KB

english, 2003

10

Amide bond surrogates: A general synthetic route to trans carbon-carbon double bono isosteres.

Youe-Kong Shue, George M. Carrera Jr., Alex M. Nadzan

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 191 KB

english, 1987

11

A traceless solid-phase synthesis of 2-imidazolones

Jie-Fei Cheng, Christopher Kaiho, Mi Chen, Thomas Arrhenius, Alex Nadzan

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 98 KB

english, 2002

12

A convenient solution and solid-phase synthesis of Δ5-2-oxopiperazines via N-acyliminium ions cyclization

Jie-Fei Cheng, Mi Chen, Thomas Arrhenius, Alex Nadzan

Journal:

Tetrahedron Letters

Year:

2002

Language:

english

File:

PDF, 95 KB

english, 2002

13

Toward developing peptidomimetics: Successful replacement of backbone amide bonds in tetrapeptide-based CCK-A receptor agonists

Kazumi Shiosaki, Chun Wel Lin, M.Robert Leanna, Howard E. Morton, Thomas R. Miller, David Witte, Michael Stashko, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 456 KB

english, 1993

14

Synthesis and structure-activity relationships of potent retinoid X receptor ligands

Luc J. Farmer, Susan Jeong, E.Adam Kallel, Stacie S. Canan Koch, Glenn E. Croston, Karen S. Flatten, Rich A. Heyman, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 320 KB

english, 1997

15

Synthesis and structure-activity relationships of potent conformationally restricted retinoid X receptor ligands

Luc J. Farmer, Lin Zhi, Susan Jeong, E. Adam Kallel, Glenn Croston, Karen S. Flatten, Rich A. Heyman, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 291 KB

english, 1997

16

Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3

Marcus F. Boehm, Patrick Fitzgerald, Aihua Zou, Marc G. Elgort, Eric D. Bischoff, Lora Mere, Dale E. Mais, Reid P. Bissonnette, Richard A. Heyman, Alex M. Nadzan, Melvin Reichman, Elizabeth A. Allegre

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 3.31 MB

english, 1999

17

Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties

Mark W. Holladay, Michael J. Bennett, Hao Bai, Jeffrey W. Ralston, James F. Kerwin Jr., Michael Stashko, Thomas R. Miller, Alyssa B. O'Neill, Alex M. Nadzan, Jorge Brioni, Chun Wel Lin

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 254 KB

english, 1995

18

Discovery and structure–activity relationship of coumarin derivatives as TNF-α inhibitors

Jie-Fei Cheng, Mi Chen, David Wallace, Sovouthy Tith, Thomas Arrhenius, Hirotaka Kashiwagi, Yoshiyuki Ono, Akira Ishikawa, Haruhiko Sato, Toshiro Kozono, Hediki Sato, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 260 KB

english, 2004

19

Aza-retinoids as novel retinoid X receptor-specific agonists

Luc J. Farmer, Kristen S. Marron, Stacie S. Canan Koch, C.K. Hwang, E Adam Kallel, Lin Zhi, Alex M. Nadzan, Dave W. Robertson, Youssef L. Bennani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 158 KB

english, 2006

20

Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors

David M. Wallace, Masayuki Haramura, Jie-Fei Cheng, Thomas Arrhenius, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 151 KB

english, 2007

21

2-Substituted fortimicins by ring opening of 2-deoxy-1,2-epimino-2-epi-fortimicin B and by nucleophilic displacements of 2-O-(methylsulfonyl)fortimicin derivatives

Jack Tadanier, Jerry R. Martin, Alex M. Nadzan, Paulett Johnson, James Holms, Robert Hallas, Ruth Stanaszek, Momir Cirovic, David Grampovnik, Alma W. Goldstein

Journal:

Carbohydrate Research

Year:

1981

Language:

english

File:

PDF, 1.17 MB

english, 1981

22

Amide bond surrogates: A novel alternate synthesis of the LEU-ASP trans carbon-carbon double bond isostere of CCK4.

Youe-Kong Shue, Michael D. Tufano, Alex M. Nadzan

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 186 KB

english, 1988

23

Retinoic acid receptor ligands based on the 6-cyclopropyl-2,4-hexadienoic acid

Luc J. Farmer, Lin Zhi, Susan Jeong, William W. Lamph, Deborah L. Osburn, Glenn Croston, Karen S. Flatten, Rich A. Heyman, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 156 KB

english, 2003

24

Double bond isosteres of the peptide bond: Synthesis and biological activity of cholecystokinin (CCK) C-terminal hexapeptide analogs

Youe-Kong Shue, Michael D. Tufano, George M. Carrera Jr, Hana Kopecka, Sharon L. Kuyper, Mark W. Holladay, Chun Wel Lin, David G. Witte, Thomas R. Miller, Mike Stashko, Alex M. Nadzan

Journal:

Bioorganic & Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 1.44 MB

english, 1993

25

Activation of specific RXR heterodimers by an antagonist of RXR homodimers

Lala, Deepak S., Mukherjee, Ranjan, Schulman, Ira G., Koch, Stacie S. Canan, Dardashti, Laura J., Nadzan, Alex M., Croston, Glenn E., Evans, Ronald M., Heyman, Richard A.

Journal:

Year:

1996

File:

PDF, 855 KB

1996

26

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

Mukherjee, Ranjan, Davies, Peter J. A., Crombie, Diane L., Bischoff, Eric D., Cesario, Rosemary M., Jow, Lily, Hamann, Lawrence G., Boehm, Marcus F., Mondon, Carl E., Nadzan, Alex M.

Journal:

Year:

1997

File:

PDF, 955 KB

1997

27

Novel methodology for the synthesis of trans-alkene dipeptide isosteres

Shue, Youe Kong, Carrera, George M., Tufano, Michael D., Nadzan, Alex M.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 730 KB

english, 1991

28

Evidence that type A CCK receptors facilitate dopamine efflux in rat brain

Thomas W. Vickroy, Bruce R. Bianchi, James F. Kerwin Jr., Hana Kopecka, Alex M. Nadzan

Journal:

European Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 131 KB

english, 1988

29

Thyrotropin releasing hormone augments growth of spinal cord transplants in oculo

Andreas Henschen, Gary Zerbe, Alex M. Nadzan, Jeffrey F. McKelvy, Lars Olson, Barry Hoffer

Journal:

Experimental Neurology

Year:

1988

Language:

english

File:

PDF, 1.17 MB

english, 1988

30

Expression, purification, and characterization of human malonyl-CoA decarboxylase

Demin Zhou, Phoebe Yuen, Donald Chu, Vicki Thon, Steve McConnell, Steven Brown, Andria Tsang, Michael Pena, Anna Russell, Jie-Fei Cheng, Alex M. Nadzan, Miguel S. Barbosa, Jason R.B. Dyck, Gary D. Lop

Journal:

Protein Expression and Purification

Year:

2004

Language:

english

File:

PDF, 419 KB

english, 2004

31

Characterization of the novel CCK analogs JMV-180, JMV-320, and JMV-332 in H345 cells

David G. Witte, Alex M. Nadzan, Jean Martinez, Marc Rodriguez, Chun Wel Lin

Journal:

Year:

1992

Language:

english

File:

PDF, 508 KB

english, 1992

32

The Intracellular Receptor and Signal Transducers and Activators of Transcription Factor Superfamilies: Novel Targets for Small-Molecule Drug Discovery

Rosen, Jonathan, Day, Adrienne, Jones, Todd K., Jones, E. Tracy Turner, Nadzan, Alex M., Stein, Robert B.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 4.05 MB

english, 1995

33

Identification of the First Retinoid X Receptor Homodimer Antagonist

Canan Koch, Stacie S., Dardashti, Laura J., Hebert, Jonathan J., White, Steven K., Croston, Glenn E., Flatten, Karen S., Heyman, Richard A., Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 363 KB

english, 1996

34

Discovery of Novel Retinoic Acid Receptor Agonists Having Potent Antiproliferative Activity in Cervical Cancer Cells

Zhang, Lin, Nadzan, Alex M., Heyman, Richard A., Love, Deborah L., Mais, Dale E., Croston, Glenn, Lamph, William W., Boehm, Marcus F.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 183 KB

english, 1996

35

Synthesis of .alpha.-benzyl .gamma.-lactam, .alpha.-benzyl .delta.-lactam, and .alpha.-benzylproline derivatives as conformationally restricted analogs of phenylalaninamide

Holladay, Mark W., Nadzan, Alex M.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 866 KB

english, 1991

36

Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells

Canan Koch, Stacie S., Dardashti, Laura J., Cesario, Rosemary M., Croston, Glenn E., Boehm, Marcus F., Heyman, Richard A., Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 109 KB

english, 1999

37

High caloric product for I.V. Administration

Nadzan, Alex M, Pernet, Andre G

Journal:

Nutrition Research

Year:

1986

Language:

english

File:

PDF, 61 KB

english, 1986

38

Analysis of Combinatorial Chemistry Samples by Micellar Electrokinetic Chromatography

Simms, Peter J., Jeffries, Cynthia T., Huang, Yujin, Zhang, Lin, Arrhenius, Thomas, Nadzan, Alex M.

Journal:

Journal of Combinatorial Chemistry

Year:

2001

Language:

english

File:

PDF, 88 KB

english, 2001

39

Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-A receptor agonists

Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Tufano, Michael D., Bianchi, Bruce R., Miller, Thomas R., Witte, David G., Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 837 KB

english, 1991

40

Cholecystokinin (CCK) antagonists: (R)-tryptophan-based hybrid antagonists of high affinity and selectivity for CCK-A receptors

Kerwin, James F., Wagenaar, Frank, Kopecka, Hana, Lin, Chun Wel, Miller, Thomas, Witte, David, Stashko, Michael, Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.14 MB

english, 1991

41

Development of potent and selective CCK-A receptor agonists from Boc-CCK-4: tetrapeptides containing Lys(N.epsilon.)-amide residues

Shiosaki, Kazumi, Lin, Chun Wel, Kopecka, Hana, Craig, Richard A., Bianchi, Bruce R., Miller, Thomas R., Witte, David G., Stashko, Michael, Nadzan, Alex M.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.03 MB

english, 1992

42

Nybomycin. 8. Biosynthetic origin of the central ring carbons studied by 13C-labeled substrates

Nadzan, Alex M., Rinehart, Kenneth L.

Journal:

Journal of the American Chemical Society

Year:

1976

Language:

english

File:

PDF, 816 KB

english, 1976

43

Nybomycin. 9. Synthetic and biosynthetic incorporation of nitrogen-15 as a means of assigning the carbon-13 nuclear magnetic resonance spectrum of nybomycin

Nadzan, Alex M., Rinehart, Kenneth L.

Journal:

Journal of the American Chemical Society

Year:

1977

Language:

english

File:

PDF, 1017 KB

english, 1977

44

Synthesis and Characterization of a Highly Potent and Selective Isotopically Labeled Retinoic Acid Receptor Ligand, ALRT1550

Bennani, Youssef L., Marron, Kristin S., Mais, Dale E., Flatten, Karen, Nadzan, Alex M., Boehm, Marcus F.

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 170 KB

english, 1998

45

3,4-Disubstituted .gamma.-lactam rings as conformationally constrained mimics of peptide derivatives containing aspartic acid or norleucine

Garvey, David S., May, Paul D., Nadzan, Alex M.

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 715 KB

english, 1990

46

An efficient synthesis of 2-methyl-5,6,7,8-tetrahydro-4H-furo[2,3-d]azepines

Shue, Youe Kong, Carrera, George M., Hutchins, Charles W., Garvey, David S., Nadzan, Alex M.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 439 KB

english, 1991

47

Photochemical epoxidation of aflatoxin B1 and sterigmatocystin: synthesis of guanine-containing adducts

Buechi, George, Fowler, Kerry W., Nadzan, Alex M.

Journal:

Journal of the American Chemical Society

Year:

1982

Language:

english

File:

PDF, 579 KB

english, 1982

48

Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists

Kerwin, James F., Nadzan, Alex M., Kopecka, Hana, Lin, Chun Wel, Miller, Thomas, Witte, David, Burt, Stanley

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 403 KB

english, 1989

49

Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists [Erratum to document cited in CA110(19):165531b]

Kerwin, James F., Nadzan, Alex M., Kopecka, Hana, Lin, Chun Wel, Miller, Thomas, Witte, David, Burt, Stanley

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 120 KB

english, 1989

50

Conformationally Constrained Amino Acids. 1 on the Synthesis of 4-Substituted 8-Membered Cyclic Tryptophan Derivatives

Chung, John Y. L., Wasicak, James T., Nadzan, Alex M.

Journal:

Synthetic Communications

Year:

1992

Language:

english

File:

PDF, 339 KB

english, 1992